Lab Publications
Chastain PD 2nd, Bowers JL, Lee DG, Bell SP, Griffith JD. Mapping Subunit
Location on the Saccharomyces cerevisiae Origin Recognition Complex Free and
Bound to DNA Using a Novel Nanoscale Biopointer. J Biol Chem. 2004 Aug
27;279(35):36354-62. 
Schubeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen
F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M. The
histone modification pattern of active genes revealed through genome-wide
chromatin analysis of a higher eukaryote. Genes Dev. 2004 Jun
1;18(11):1263-71.
Wilmes GM, Archambault V, Austin RJ, Jacobson MD, Bell SP, Cross FR.
Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the
initiator protein Orc6 provides an origin-localized replication control switch.
Genes Dev. 2004 May 1;18(9):981-91.
Lau A, Blitzblau H, Bell SP. Cell-cycle control of the establishment of
mating-type silencing in S. cerevisiae. Genes Dev. 2002 Nov
15;16(22):2935-45.
Claycomb JM, MacAlpine DM, Evans JG, Bell SP, Orr-Weaver TL. Visualization
of replication initiation and elongation in Drosophila. J Cell Biol. 2002 Oct
28;159(2):225-36.
Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem.
2002;71:333-74.
Bell SP. The origin recognition complex: from simple origins to complex
functions. Genes Dev. 2002 Mar 15;16(6):659-72.
Wilmes GM, Bell SP. The B2 element of the Saccharomyces cerevisiae ARS1
origin of replication requires specific sequences to facilitate pre-RC
formation. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):101-6.
Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP,
Aparicio OM. Genome-wide distribution of ORC and MCM proteins in S.
cerevisiae: high-resolution mapping of replication origins. Science. 2001 Dec
14;294(5550):2357-60.
Schwacha A, Bell SP. Interactions between two catalytically distinct MCM
subgroups are essential for coordinated ATP hydrolysis and DNA replication.
Mol Cell. 2001 Nov;8(5):1093-104.
Klemm RD, Bell SP. ATP bound to the origin recognition complex is important
for preRC formation. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8361-7.
Lipford JR, Bell SP. Nucleosomes positioned by ORC facilitate the
initiation of DNA replication. Mol Cell. 2001 Jan;7(1):21-30.
Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J,
Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA.
Genome-wide location and function of DNA binding proteins. Science. 2000 Dec
22;290(5500):2306-9.
Lee DG, Makhov AM, Klemm RD, Griffith JD, Bell SP. Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding. EMBO J. 2000 Sep 1;19(17):4774-82.
Lee DG, Bell SP. ATPase switches controlling DNA replication initiation. Curr Opin Cell Biol. 2000 Jun;12(3):280-5.
Austin RJ, Orr-Weaver TL, Bell SP. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element. Genes Dev. 1999 Oct 15;13(20):2639-49.
Aparicio OM, Stout AM, Bell SP. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9130-5.
Royzman I, Austin RJ, Bosco G, Bell SP, Orr-Weaver TL. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 1999 Apr 1;13(7):827-40.
Baker TA, Bell SP. Polymerases and the replisome: machines within machines. Cell. 1998 Feb 6;92(3):295-305.
Dutta A, Bell SP. Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol. 1997;13:293-332. Review.
Lee DG, Bell SP. Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol. 1997 Dec;17(12):7159-68.
Aparicio OM, Weinstein DM, Bell SP. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell. 1997 Oct 3;91(1):59-69.
Klemm RD, Austin RJ, Bell SP. Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell. 1997 Feb 21;88(4):493-502.